Born in Mumbai into a Mangalorean Catholic family, D'Souza was raised a Roman Catholic in the Bandra suburb of Mumbai. Her mother Jeanette D'Souza was formerly a managing director of the Pharma Multinational corporation (MNC), who left her job in 2004 to help Genelia with her career. Her father Neil D'Souza, is a senior official with Tata Consultancy Services (TCS).[8] She also has a younger brother, Nigel D'Souza, who works with the Bombay Stock Exchange. According to D'Souza, her name "Genelia", means "rare" or "unique", and is a portmanteau of Jeanette and Neil, her mother and father's name. She is also often informally referred to as Geenu, her nickname.[12] D'Souza studied at the Apostolic Carmel High School in Bandra and later joined St. Andrew's College in Bandra to pursue her Bachelor's Degree of Management Studies. She completed her degree while shooting for her first film, Tujhe Meri Kasam in 2003 and initially thought that an MNC job would suit her. She liked sports and studies in college, and was a state level athlete, sprinter, and a national level football player.